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Anti -CUG-BP1 Rabbit pAb for IHC IF primary antibody

Specification: 100uL
Applications:IHC、IF
  • GB112305
  • Servicebio
  • Servicebio

Description

Product Information

 

Description

CUG-BP1 rabbit polyclonal

Protein full name

CUGBP Elav-like family member 1

Synonyms

CELF-1, 50 kDa nuclear polyadenylated RNA-binding protein, Brain protein F41, Bruno-like protein 2, CUG-BP1, CUG-BP- and ETR-3-like factor 1, EDEN-BP homolog, Brunol2, Cugbp, Cugbp1, Celf1

Immunogen

KLH conjugated Synthetic peptide

corresponding to Mouse CUG-BP1

Isotype

IgG

Purity

Affinity purification

Subcellular location

CytoplasmNucleus

Uniprot ID

P28659, Q4QQT3


 

Applications

 

Applications

Species

Dilution

Positive Tissue

IHC

Mouse, Rat

1: 200-1: 400

brain, heart, substantia nigra

IF

Mouse, Rat

1: 200-1: 400

brain, heart, spleen


 

Background

 

CUG-BP1, an RNA CUG triplet repeat binding protein, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the DMPK in DM is associated with alterations in binding activity of CUG-BP1 as well as alterations in the translation of the C/EBPb transcription factor. CUG-BP1 is an important regulator of initiation from different AUG codons of C/EBPb mRNA. In normal cells, CUG-BP1 up-regulates the p21 protein during differentiation by inducing the translation of p21 via binding to a GC-rich sequence located within the 5’ region of p21 mRNA.

 


 

Images

 

Immunohistochemistry analysis of paraffin-embedded mouse brain using 

CUG-BP1 (GB112305) at dilution of 1: 400

Immunohistochemistry analysis of paraffin-embedded mouse heart using 

CUG-BP1 (GB112305) at dilution of 1: 400

Immunohistochemistry analysis of paraffin-embedded rat heart using 

CUG-BP1 (GB112305) at dilution of 1: 400

Immunohistochemistry analysis of paraffin-embedded rat substantia nigra using CUG-BP1 (GB112305) at dilution of 1: 400

Immunofluorescent analysis of paraformaldehyde-fixed mouse brain using 

CUG-BP1 (GB112305) at dilution of 1: 200

Immunofluorescent analysis of paraformaldehyde-fixed rat brain using 

CUG-BP1 (GB112305) at dilution of 1: 200

Immunofluorescent analysis of paraformaldehyde-fixed mouse heart using 

CUG-BP1 (GB112305) at dilution of 1: 200

Immunofluorescent analysis of paraformaldehyde-fixed rat spleen using 

CUG-BP1 (GB112305) at dilution of 1: 200

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

 

NOTE: This product is intended for research only.

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