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GB11238-2 Anti -Cdk4 PSK-J3 CMM3 Cyclin dependent kinase 4 Rabbit Polyclonal Antibody for IHC IF

Immunogen:  KLH conjugated Synthetic peptide corresponding to Mouse CDK4
Isotype: IgG
Purity: Affinity purification

 

ul:
  • GB11238-2
  • Servicebio

Description

Product Information


Description

Cdk4 rabbit polyclonal

Protein full name

Cyclin-dependent kinase 4

Synonyms

CDK4, CMM3, PSK-J3, cyclin-dependent

kinase 4, cyclin dependent kinase 4

Immunogen

KLH conjugated Synthetic peptide

corresponding to Mouse CDK4

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm, Nucleus, Membrane

Uniprot ID

P11802, P30285, P35426




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Human, Rat

1: 100

colon, breast, stomach, testis, ovary

IF

Human, Rat

1: 100

colon, breast, stomach, testis, ovary




Background


The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.



Images



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Immunohistochemistry analysis of paraffin-embedded human colon using CDK4 (GB11238-2) at dilution of 1: 100

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Immunohistochemistry analysis of paraffin-embedded human breast using CDK4 (GB11238-2) at dilution of 1: 100

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Immunohistochemistry analysis of paraffin-embedded human stomach cancer using CDK4 (GB11238-2) at dilution of 1: 100

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Immunohistochemistry analysis of paraffin-embedded rat testis using CDK4 (GB11238-2) at dilution of 1: 100

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Immunohistochemistry analysis of paraffin-embedded rat ovary using CDK4 (GB11238-2) at dilution of 1: 100

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Immunohistochemistry analysis of paraffin-embedded rat spleen using CDK4 (GB11238-2) at dilution of 1: 100




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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