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GB112380 Anti -p115-RhoGEF Lbcl2 Lsc Rabbit Polyclonal Antibody for WB

Immunogen: KLH conjugated Synthetic peptide corresponding to Human p115-RhoGEF
Isotype: IgG
Purity: Affinity purification
ul:
  • GB112380
  • Servicebio

Description

Product Information


Description

p115-RhoGEF rabbit polyclonal

Protein full name

Rho guanine nucleotide exchange factor 1

Synonyms

Lbc's second cousin, Lymphoid blast crisis-like 2, Arhgef1, Lbcl2, Lsc, 115 kDa guanine nucleotide exchange factor, GEF1, Lsc homolog

Immunogen

KLH conjugated Synthetic peptide corresponding to Human p115-RhoGEF

Isotype

IgG

Purity

Affinity purification

Predicted MW.

103 kDa

Observed MW.

80 kDa

Uniprot ID

Q92888




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human

1: 1000-1: 2000

HeLa, 293T, A549, McF7 




Background


This gene seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.




Images


图片 1.png

Western blot analysis of p115-RhoGEF (GB112380) at dilution of 1: 2000

Lane 1: HeLa cell lysate

Lane 2: 293T cell lysate

Lane 3: A549 cell lysate

Lane 4: McF7 cell lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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