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GB112387 Anti -ClC-5 Chloride channel protein 5 Clcn5 Rabbit Polyclonal Antibody for IHC

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse ClC-5
Isotype: IgG
Purity: Affinity purification
ul:
  • GB112387
  • Servicebio

Description

Product Information


Description

ClC-5 rabbit polyclonal

Protein full name

H(+)/Cl(-) exchange transporter 5

Synonyms

Chloride channel protein 5, ClC-5, Chloride transporter ClC-5, Clcn5, Clc5, Voltage gated chloride ion channel CLCN5, NPHL1

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse ClC-5

Isotype

IgG

Purity

Affinity purification

Subcellular location

Golgi apparatus, Endosome, Cell membrane

Uniprot ID

Q9WVD4, P51796




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Human, Rat

1: 100-1: 200

kidney




Background


The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume.Mutations in the gene encoding CLC1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC2 is highly expressed in the epithelia of several organs including lung, which suggests CLC2 may be a possible therapeutic target for cystic fibrosis. CLC3 expression is particularly abundant in neuronal tissue, while CLC4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC5 lead to Dent’s disease, a renal disorder characterized by proteinuria and hypercalciuria.




Images



Immunohistochemistry analysis of paraffin-embedded human kidney using 

ClC-5 (GB112387) at dilution of 1: 200

Immunohistochemistry analysis of paraffin-embedded rat kidney using 

ClC-5 (GB112387) at dilution of 1: 200




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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