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GB112400 Anti -Lamin A + Lamin C LGMD1B LFP Rabbit Polyclonal Antibody for WB

Immunogen: Recombinant protein corresponding to Mouse Lamin A + Lamin C
Isotype: IgG
Purity: Affinity purification
ul:
  • GB112400
  • Servicebio

Description

Product Information


Description

Lamin A + Lamin C rabbit polyclonal

Protein full name

Prelamin-A/C

Synonyms

Lamin-A/C, Lmna, Lmn1, Cardiomyopathy dilated 1A (autosomal dominant), LGMD1B, LFP, LMNA, Renal carcinoma antigen NYREN32

Immunogen

Recombinant protein corresponding to Mouse Lamin A + Lamin C

Isotype

IgG

Purity

Affinity purification

Predicted MW.

74 kDa

Observed MW.

70 kDa

Uniprot ID

P48678




Applications


Applications

Species

Dilution

Positive Tissue

WB

Mouse

1: 500-1: 1000

liver, colon




Background


The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.




Images


图片 1.png

Western blot analysis of Lamin A + Lamin C (GB112400) at dilution of 1: 1000

Lane 1: NIH3T3 cell lysate

Lane 2: Mouse liver tissue lysate

Lane 3: Mouse colon tissue lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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