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GB11247 Anti -MMP13 Collagenase 3 CLG3 MANDP1 Rabbit Polyclonal Antibody for IHC IF

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse MMP13
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11247
  • Servicebio

Description

Product Information


Description

MMP13 rabbit polyclonal

Protein full name

Collagenase 3

Synonyms

Collagenase 3, MMP13, CLG3, MANDP1,

MMP-13, Matrix metallopeptidase 13, MDST

Immunogen

KLH conjugated Synthetic peptide

corresponding to Mouse MMP13

Isotype

IgG

Purity

Affinity purification

Subcellular location

Secreted

Uniprot ID

P33435, P23097




Applications


applications

species

dilution

Positive tissue

IHC

Mouse, Rat

1: 200

bone

IF

Mouse, Rat

1: 200

bone




Background


Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.



Images



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Immunohistochemistry analysis of paraffin-embedded rat bone using MMP13 (GB11247) at dilution of 1:200

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Immunohistochemistry analysis of paraffin-embedded mouse bone using MMP13 (GB11247) at dilution of 1:200




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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