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GB11252 Anti -BMP2 BDA2 BMP2A Rabbit Polyclonal Antibody

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse BMP2 
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11252
  • Servicebio

Description

Product Information


Description

BMP2 rabbit polyclonal

Protein full name

Bone morphogenetic protein 2

Synonyms

BMP2, BDA2, BMP2A,

bone morphogenetic protein 2

Immunogen

KLH conjugated Synthetic peptide

corresponding to Mouse BMP2

Isotype

IgG

Predicted MW.

45 kDa

Observed MW.

45 kDa

Purity

Affinity purification

Subcellular location

Secreted

Uniprot ID

P12643, P21274, P49001




Applications


applications

species

dilution

Positive tissue

WB

Human, Mouse, Rat

1: 1000

liver, spleen, lung

IHC

Mouse, Rat

1: 200-1: 1000

bone

IF

Mouse, Rat

1: 200-1: 1000

bone




Background


Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.



Images



blob.png

Western blot analysis of BMP2 GB11252) at dilution of 1:1000.

Lane1:U251 cell lysate

Lane2:Hela cell lysate

Lane3:MCF7 cell lysate

Lane 4:Mouse liver tissue lysate

Lane 5:Mouse spleen tissue lysate

Lane 6:Mouse lung tissue lysate

Lane 7:Rat liver tissue lysate

Lane 8:Rat spleen tissue lysate

Lane 9:Rat lung tissue lysate

blob.png

Immunohistochemistry analysis of paraffin-embedded mouse bone marrow using BMP2(GB11252) at dilution of 1:500

blob.png

Immunohistochemistry analysis of paraffin-embedded mouse bone using BMP2(GB11252) at dilution of 1:500




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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