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Anti -Progesterone receptor Rabbit pAb for Immunohistochemistry Primary antibody

Specification: 100uL
  • GB11262
  • Servicebio
  • Servicebio

Description

Product Information


Description

Progesterone receptor rabbit polyclonal

Protein full name

Progesterone receptor

Synonyms

PGR, NR3C3, PR, progesterone receptor

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse Progesterone receptor

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus, Cytoplasm

Uniprot ID

Q00175, Q63449, P06401




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Human, Mouse, Rat

1: 500-1: 1000

endometrial cancer, uterus




Background


Progesterone is necessary to induce the progesterone receptors. When no binding hormone is present the carboxyl terminal inhibits transcription. Binding to a hormone induces a structural change that removes the inhibitory action. Progesterone antagonists prevent the structural reconfiguration.

After progesterone binds to the receptor, restructuring with dimerization follows and the complex enters the nucleus and binds to DNA. There transcription takes place, resulting in formation of messenger RNA that is translated by ribosomes to produce specific proteins.




Images



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Immunohistochemistry analysis of paraffin-embedded human endometrial cancer using Progesterone receptor (GB11262) at dilution of 1: 500

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Immunohistochemistry analysis of paraffin-embedded human uterus using Progesterone receptor (GB11262) at dilution of 1: 500

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Immunohistochemistry analysis of paraffin-embedded mouse uterus using Progesterone receptor (GB11262) at dilution of 1: 1000




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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