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Anti -RUNX2 Rabbit pAb for IHC IF WB Polyclonal antibody

Specification: 100uL
  • GB11264
  • Servicebio
  • Servicebio

Description

Product Information

 

 

Description

RUNX2 rabbit polyclonal

Protein full name

Runt-related transcription factor 2

Synonyms

AML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD, OSF-2, OSF2, PEA2aA, PEBP2aA

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse RUNX2

Isotype IgG
Purity Affinity purification
Subcellular location

Nucleus

Uniprot ID

Q08775,Q9Z2J9

 


 

Applications

 

 

Applications

IHC,IF

Species

Mouse,Rat

Dilution

1:200-1:500

Positive tissue

bone

 


 

Background

 

 

Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation (By similarity). In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).

 


 

Images

 

 

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Immunohistochemistry analysis of paraffin-embedded rat bone tissue using RUNX2 (GB11264) at dilution of 1:500

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Immunohistochemistry analysis of paraffin-embedded mouse bone using RUNX2 (GB11264) at dilution of 1:500

 

 


 

Storage

 

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

 


 

NOTE: This product is intended for research only.

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