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Anti - ROCK1 Rabbit PAb for IHC IF Primary Antibody

Specification: 100uL
  • GB11265
  • Servicebio
  • Servicebio

Description

Product Information


Description

ROCK1 rabbit polyclonal

Protein full name

Rho-associated protein kinase 1

Synonyms

P160ROCK, ROCK-I, Rho associated coiled-coil containing protein kinase 1, Rock1

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse ROCK1

Isotype

IgG

Purity

Affinity purification

Subcellular location

Golgi apparatus membrane, Cytoplasm,

Cell projection

Uniprot ID

P70335, Q63644




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Mouse, Rat

1: 100-1: 400

spleen, kidney

IF

Mouse, Rat

1: 100-1: 400

spleen, kidney




Background


Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation.Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.



Images



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Immunohistochemistry analysis of paraffin-embedded rat kidney using ROCK1 (GB11265) at dilution of 1: 300

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Immunohistochemistry analysis of paraffin-embedded rat spleen using ROCK1(GB11265) at dilution of 1: 300

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Immunohistochemistry analysis of paraffin-embedded mouse kidney using ROCK1 (GB11265) at dilution of 1: 300




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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