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Anti -Fos B Rabbit pAb

  • Servicebio

Description

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Product Information

Description

Fos B rabbit polyclonal

Protein full name

Protein fosB

Synonyms

FOSB, AP-1, G0S3, GOS3, GOSB, FosB, ΔFosB, FosB proto-oncogene, AP-1 transcription factor subunit

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse FOSB

Isotype

IgG

Predicted MW.

36 kDa

Observed MW.

36 kDa

Purity

Affinity purification

Uniprot ID

P53539, P13346



Applications

Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 1000

liver cancer



Background

The FOS gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipperproteins that can dimerize with proteins of the JUN family (e.g., c-Jun, JunD), thereby forming thetranscription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. FosB and its truncated splice variants, ΔFosB and further truncated Δ2ΔFosB, are all involved in osteosclerosis, although Δ2ΔFosB lacks a knowntransactivation domain, in turn preventing it from affecting transcription through the AP-1 complex.


Images

图片 3.png

Western blot analysis of Fos B (GB11270) at dilution of 1: 1000.

Lane 1: HeLa cell lysate

Lane 2: HepG2 cell lysate

Lane 3:Mice hela tumor tissue lysate

Lane 4: Mice HepG2 tumor tissue lysate

Lane 5: Human liver cancer tissue lysate


Storage

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.


NOTE: This product is intended for research only.

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