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Anti -Hsp90 Rabbit PAb for Western Blot Primary Antibody

Specification: 100uL
  • GB11284-1
  • Servicebio
  • Servicebio

Description

Product Information


Description

HSP90 rabbit polyclonal

Protein full name

Heat shock protein HSP 90-alphav

Synonyms

HSP90AA1, EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP-2, LAP2, HEL-S-65p, Heat shock protein 90kDa alpha

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse HSP90A

Isotype

IgG

Predicted MW.

90 kDa

Observed MW.

90 kDa

Purity

Affinity purification

Uniprot ID

P07900, P82995, P07901




Applications


Applications

Species

Dilution

Positive Ttissue

WB

Human, Mouse, Rat

1: 500-1: 1000

colon cancer, brain




Background


Complemented by the constitutively expressed paralog Hsp90B which shares over 85% amino acid sequence identity, Hsp90A expression is initiated when a cell experiences proteotoxic stress. Once expressed Hsp90A dimers operate as molecular chaperones that bind and fold other proteins into their functional 3-dimensional structures. This molecular chaperoning ability of Hsp90A is driven by a cycle of structural rearrangements fueled by ATP hydrolysis. Current research on Hsp90A focuses in its role as a drug target due to its interaction with a large number of tumor promoting proteins and its role in cellular stress adaptation.



Images



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Western blot analysis of HSP90 (GB11284-1) at dilution of 1: 1000.

Lane 1: HeLa cell lysate

Lane 2: HepG2 cell lysate

Lane 3: MCF7 cell lysate

Lane 4: Human colon cancer tissue lysate

Lane 5: Mouse colon tissue lysate

Lane 6: Mouse brain tissue lysate

Lane 7: Rat brain tissue lysate




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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