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Anti -IKK alpha Rabbit pAb Western blot antibody

Specification: 100uL
Protein full name: Inhibitor of nuclear factor kappa-B kinase subunit alpha
  • GB11292-1
  • Servicebio
  • Servicebio

Description

Product Information


Description

IKK alpha rabbit polyclonal

Protein full name

Inhibitor of nuclear factor kappa-B kinase subunit alpha

Synonyms

CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16, conserved helix-loop-helix ubiquitous kinase

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse IKKα

Isotype

IgG

Predicted MW.

85 kDa

Observed MW.

85 kDa

Purity

Affinity purification

Uniprot ID

O15111, Q60680




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human,

Mouse, Rat

1: 500-1: 1000

lung




Background


IKK-α is a member of the serine/threonine protein kinase family and forms a complex in the cell with IKK-βand NEMO. NF-κB transcription factors are normally held in an inactive state by the inhibitory proteins IκBs. IKK-α and IKK-β phosphorylate the IκB proteins, marking them for degradation via ubiquitination and allowing NF-κB transcription factors to go into the nucleus.

Once activated, NF-κB transcription factors regulate genes that are implicated in many important cellular processes, including immune response, inflammation, cell death, and cell proliferation.

   



Images



GB11292-1.png

Western blot analysis of IKKα (GB11292-1) at dilution of 1: 1000.

Lane 1: HeLa cell lysate

Lane 2: HepG2 cell lysate

Lane 3: HCT116 cell lysate

Lane 4: Mouse lung tissue lysate

Lane 5: Rat lung tissue lysate




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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