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Anti -IKK alpha Rabbit pAb for IHC IF IKK alpha rabbit polyclonal

Specification: 100uL
  • GB11292-2
  • Servicebio
  • Servicebio

Description

Product Information


Description

IKK alpha rabbit polyclonal

Protein full name

Inhibitor of nuclear factor kappa-B kinase subunit alpha

Synonyms

CHUK, IKBKA, IKK-alpha, IKK1, IKKA,NFKBIKA, TCF16, conserved helix-loop-helix ubiquitous kinase

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse IKKα

Isotype

IgG

Subcellular location

Cytoplasm, Nucleus

Purity

Affinity purification

Uniprot ID

O15111, Q60680




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Human

1: 200-1: 600

lung cancer, colon cancer, breast cancer

IF

Human

1: 200-1: 600

lung cancer, colon cancer, breast cancer




Background


IKK-α is a member of the serine/threonine protein kinase family and forms a complex in the cell with IKK-β and NEMO. NF-κB transcription factors are normally held in an inactive state by the inhibitory proteins IκBs. IKK-α and IKK-β phosphorylate the IκB proteins, marking them for degradation via ubiquitination and allowing NF-κB transcription factors to go into the nucleus.

Once activated, NF-κB transcription factors regulate genes that are implicated in many important cellular processes, including immune response, inflammation, cell death, and cell proliferation.



Images



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Immunohistochemistry analysis of paraffin-embedded human lung cancer using IKKα (GB11292-2) at dilution of 1: 600

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Immunohistochemistry analysis of paraffin-embedded human colon cancer using IKKα (GB11292-2) at dilution of 1: 600

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Immunohistochemistry analysis of paraffin-embedded human breast cancer using IKKα (GB11292-2) at dilution of 1: 600




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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