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Anti -Integrin alpha V Rabbit pAb Cell Ligation Research Western blot antibody

Specification: 100uL
  • GB11293-1
  • Servicebio
  • Servicebio

Description

Product Information


Description

Integrin alpha V rabbit polyclonal

Protein full name

Integrin alpha-V

Synonyms

ITGAV, CD51, MSK8, VNRA, VTNR, integrin subunit alpha V

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse Integrin alpha-V

Isotype

IgG

Predicted MW.

116 kDa

Observed MW.

130 kDa

Purity

Affinity purification

Uniprot ID

P06756, P43406




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse

1: 500-1: 1000

HUVEC, A549,

HT29, kidney




Background


The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling . ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling . ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1.




Images



GB11293-1.png

Western blot analysis of Integrin alpha V (GB11293-1) at dilution of 1:600.

Lane 1: HUVEC cell lysate

Lane 2: A549 cell lysate

Lane 3: HT29 cell lysate

Lane 4: Mouse lung tissue lysate

Lane 5: Mouse kidney tissue lysate




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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