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Anti -Integrin Alpha V Rabbit PAb for IHC IF Primary Antibody

Specification:100uL
  • GB11293-2
  • Servicebio
  • Servicebio

Description

Product Information


Description

Integrin alpha V rabbit polyclonal

Protein full name

Integrin alpha-V

Synonyms

ITGAV, CD51, MSK8, VNRA, VTNR, integrin subunit alpha V

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse Integrin alpha-V

Isotype

IgG

Subcellular location

Membrane, Cell junction

Purity

Affinity purification

Uniprot ID

P06756, P43406




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Human, Mouse, Rat

1: 500-1: 1000

liver cancer,

kidney, brain

IF

Human, Mouse, Rat

1: 500-1: 1000

liver cancer,

kidney, brain




Background


The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling . ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling . ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1.




Images



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Immunohistochemistry analysis of paraffin-embedded human liver  cancer using Integrin alpha V (GB11293-2) at dilution of 1: 500

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Immunohistochemistry analysis of paraffin-embedded human kidney using Integrin alpha V (GB11293-2) at dilution of 1: 1000

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Immunohistochemistry analysis of paraffin-embedded mouse kidney using Integrin alpha V (GB11293-2) at dilution of 1: 1000




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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