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Anti -TrkB Rabbit pAb Western blot antibody

Specification: 100uL
  • GB11295-1
  • Servicebio
  • Servicebio

Description

Product Information


Description

TrkB rabbit polyclonal

Protein full name

BDNF/NT-3 growth factors receptor

Synonyms

NTRK2, GP145-TrkB, TRKB, trk-B, neurotrophic receptor tyrosine kinase 2, OBHD

Immunogem

Recombinant protein corresponding to Mouse TRKB

Isotype

IgG

Predicted MW.

92 kDa

Observed MW.

90/140 kDa

Purity

Affinity purification

Uniprot ID

P15209, Q63604, Q16620




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

liver, brain, spinal marrow




Background


Tropomyosin receptor kinase B is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations. The neurotrophins that activate TrkB are: BDNF (Brain Derived Neurotrophic Factor), neurotrophin-4 (NT-4), andneurotrophin-3 (NT-3). As such, TrkB mediates the multiple effects of these neurotrophic factors, which includes neuronal differentiation and survival. Research has shown that activation of the TrkB receptor can lead to down regulation of the KCC2 chloride transporter in cells of the CNS.

   



Images



GB11295-1.png

Western blot analysis of TrkB

(GB11295-1) at dilution of 1: 1000.

Lane 1: HepG2 cell lysate

Lane 2: HACAT cell lysate

Lane 3: SH-SY5Y cell lysate

Lane 4: Mouse liver tissue lysate

Lane 5: Mouse spinal marrow tissue lysate

Lane 6: Mouse brain tissue lysate

Lane 7: Rat liver tissue lysate

Lane 8: Rat spinal marrow tissue lysate

Lane 9: Rat brain tissue lysate




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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