PHONE

+86(027) 5111 3188

Share to:

Anti -NLRP3 Rabbit pAb for IHC IF Polyclonal antibody

Specification: 100uL
  • GB11300
  • Servicebio
  • Servicebio

Description

Product Information


Description

NLRP3 rabbit polyclonal

Protein full name

NACHT, LRR and PYD domains-containing protein 3

Synonyms

NLRP3, AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCAS1, FCU, MWS, NALP3, PYPAF1, NLR family, pyrin domain containing 3, NLR family pyrin domain containing 3

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse NLRP3

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm, Secreted, Nucleus

Uniprot ID

Q96P20, Q8R4B8




Applications


applications

species

dilution

Positive tissue

IHC

Human, Mouse

1: 600-1: 1200

tonsil, spleen

IF

Human, Mouse

1: 600-1: 1200

tonsil, spleen




Background


NALP3 is a component of the innate immune system that functions as a pathogen recognition receptor (PRR) that recognizes pathogen-associated molecular patterns (PAMPs). NALP3 belongs to the NOD-like receptor (NLR) subfamily of PRRs and NALP3 together with the adaptor ASC protein PYCARD forms a caspase-1 activating complex known as the NALP3 inflammasome. NALP3 in the absence of activating signal is kept in an inactive state complexed with HSP90 and SGT1 in the cytoplasm. NALP3 inflammasome detects danger signals such as crystallineuric acid and extracellular ATP released by damaged cells. These signals release of HSP90 and SGT1 from and recruit ASC protein and caspase-1 to the inflammasome complex.



Images



blob.png

Immunohistochemistry analysis of paraffin-embedded Human tonsil using NLRP3 (GB11300) at dilution of 1:1200

blob.png

Immunohistochemistry analysis of paraffin-embedded mouse spleen using NLRP3 (GB11300) at dilution of 1:1200




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

downLoadImgSlice 13Slice 10Laboratory(1)Slice 12

Contact us

Quick Links

Product Category

Get In Touch

 5th Floor, 22 Building, Biopark, Gaoxin 2nd Road No. 388, East Lake High-Tech Developing Zone, Wuhan, Hubei, China 430079
 +86(027) 5111 3188
Copyright © 2021  Wuhan Servicebio Technology Co., Ltd.