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Anti -Cyclin E1 Rabbit pAb For IHC IF Cell Cycle Research Antibody

Specification: 100uL
  • GB11305
  • Servicebio
  • Servicebio

Description

Product Information


Description

Cyclin E1 rabbit polyclonal

Protein full name

G1/S-specific cyclin-E1

Synonyms

CCNE1, CCNE, pcyclin E1, Cyclin E1

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse Cyclin E1

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus

Uniprot ID

P24864, Q61457




Applications


applications

species

dilution

Positive tissue

IHC

Human

1: 1000-1: 2000

orchidoncus

IF

Human

1: 1000-1: 2000

orchidoncus




Background


The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB.



Images



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Immunohistochemistry analysis of paraffin-embedded human orchidoncus using Cyclin E1 (GB11305) at dilution of 1:1000.




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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