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Anti -Amyloid beta precursor protein Rabbit pAb for IHC IF

Specification:100uL 
  • GB11307
  • Servicebio
  • Servicebio

Description

Product Information


Description

Amyloid beta precursor protein

rabbit polyclonal

Protein full name

Amyloid beta A4 protein

Synonyms

APP, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, amyloid beta precursor protein, preA4, β-Amyloid

Immunogen

Recombinant protein corresponding to Mouse Amyloid beta precursor protein (APP)

Isotype

IgG

Purity

Affinity purification

Subcellular location

Membrane

Uniprot ID

P12023, P08592




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Mouse, Rat

1: 500-1: 1000

brain

IF

Mouse, Rat

1: 500-1: 1000

brain




Background


Functions as a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis.




Images



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Immunohistochemistry analysis of paraffin-embedded Rat brain using APP(GB11307) at dilution of 1: 500

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Immunohistochemistry analysis of paraffin-embedded mouse brain using APP (GB11307) at dilution of 1: 500




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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