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Anti -AIF Rabbit pAb for IHC IF Apoptosis detection antibody

Specification: 100uL
  • GB11314
  • Servicebio
  • Servicebio

Description

Product Information


Description

AIF rabbit polyclonal

Protein full name

Apoptosis-inducing factor 1, mitochondrial

Synonyms

AIFM1, AIF, CMT2D, CMTX4, COWCK, COXPD6, NADMR, NAMSD, PDCD8, DFNX5, apoptosis inducing factor, mitochondria associated 1, apoptosis inducing factor mitochondria associated 1

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse AIF

Isotype

IgG

Purity

Affinity purification

Subcellular location

Mitochondrion intermembrane space. Mitochondrion inner membrane. Cytoplasm. Nucleus.

Uniprot ID

O95831, Q9Z0X1, Q9JM53




Applications


applications

species

dilution

Positive tissue

IHC

Human, Mouse, Rat

1: 500-1: 1500

tonsil, spleen

IF

Human, Mouse, Rat

1: 500-1: 1500

tonsil, spleen




Background


Probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e., caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.



Images



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Immunohistochemistry analysis of paraffin-embedded human Tonsil using AIF(GB11314) at dilution of 1:1500

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Immunohistochemistry analysis of paraffin-embedded Rat spleen using AIF(GB11314) at dilution of 1:1500

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Immunohistochemistry analysis of paraffin-embedded mouse spleen using AIF(GB11314) at dilution of 1:1500




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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