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Anti -ATF2 Rabbit PAb for IHC IF Primary Antibody

Specification: 100uL
  • GB11315-1
  • Servicebio
  • Servicebio

Description

Product Information


Description

ATF2 rabbit polyclonal

Protein full name

Cyclic AMP-dependent transcription factor ATF-2

Synonyms

ATF2, CRE-BP1, CREB-2, CREB2, HB16, TREB7, activating transcription factor 2

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse ATF2

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus.Cytoplasm.Mitochondrion outer membrane

Uniprot ID

P16951, Q00969




Applications


applications

species

dilution

Positive tissue

IHC

Mouse, Rat

1: 500-1: 1000

lung cancer, breast cancer, kidney, brain

IF

Mouse, Rat

1: 500-1: 1000

lung cancer, breast cancer, kidney, brain




Background


A transcription factor that is a member of the leucine zipper family of DNA binding proteins. The protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation.



Images



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Immunohistochemistry analysis of paraffin-embedded rat brain using ATF2(GB11315-1) at dilution of 1:1000

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Immunohistochemistry analysis of paraffin-embedded mouse brain using ATF2(GB11315-1) at dilution of 1:1000




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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