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Anti -DLL1 Rabbit pAb for IHC IF polyclonal antibody

Specification: 100uL
  • GB11320
  • Servicebio
  • Servicebio

Description

Product Information


Description

DLL1 rabbit polyclonal

Protein full name

Delta-like protein 1

Synonyms

DLL1, DELTA1, DL1, Delta, Delta-like 1, delta like canonical Notch ligand 1

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse DLL1

Isotype

IgG

Purity

Affinity purification

Subcellular location

Apical cell membrane,

Cell junction, Membrane raft

Uniprot ID

Q61483, P97677




Applications


applications

species

dilution

Positive tissue

IHC

Mouse, Rat

1: 200-1: 500

brain, spinal marrow

IF

Mouse, Rat

1: 200-1: 500

brain, spinal marrow




Background


Notch signaling is activated upon engagement of the Notch receptor with its ligands, the DSL (Delta, Serrate, Lag2) proteins of single-pass type I membrane proteins. The DSL proteins contain multiple EGF-like repeats and a DSL domain that is required for binding to Notch. Five DSL proteins have been identified in mammals: Jagged1, Jagged2, Delta-like (DLL) 1, 3 and 4. Ligand binding to the Notch receptor results in two sequential proteolytic cleavages of the receptor by the ADAM protease and the γ-secretase complex. The intracellular domain of Notch is released and then translocates to the nucleus where it activates transcription. Notch ligands may also be processed in a way similar to Notch, suggesting a bi-directional signaling through receptor-ligand interactions.




Images



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Immunohistochemistry analysis of paraffin-embedded rat brain using DLL1 (GB11320) at dilution of 1:400

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Immunohistochemistry analysis of paraffin-embedded rat spinal marrow using DLL1 (GB11320) at dilution of 1:400


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Immunohistochemistry analysis of paraffin-embedded mouse brain using DLL1 (GB11320) at dilution of 1:400

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Immunohistochemistry analysis of paraffin-embedded mouse spinal marrow using DLL1 (GB11320) at dilution of 1:400




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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