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Anti -Dnmt1 Rabbit pAb for IHC IF Dnmt1 rabbit polyclonal

Specification: 100uL
  • GB11328
  • Servicebio
  • Servicebio

Description

Product Information


Description

Dnmt1 rabbit polyclonal

Protein full name

DNA (cytosine-5)-methyltransferase 1

Synonyms

DNA (cytosine-5-)-methyltransferase 1,DNA methyltransferase 1, DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse Dnmt1

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus

Uniprot ID

P13864, P26358




Applications


applications

species

dilution

Positive tissue

IHC

Human

1: 500-1: 1000

liver cance, lung cancer

IF

Human

1: 500-1: 1000

liver cance, lung cancer




Background


Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.




Images



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Immunohistochemistry analysis of paraffin-embedded human lung cancer  using Dnmt1 (GB11328) at dilution of 1:800

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Immunohistochemistry analysis of paraffin-e mbedded human liver cancer  using Dnmt1 (GB11328) at dilution of 1:800

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Immunohistochemistry analysis of paraffin-embedded human breast cancer using Dnmt1 (GB11328) at dilution of 1:800

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Immunohistochemistry analysis of paraffin-embedded human kidney  using Dnmt1 (GB11328) at dilution of 1:800




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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