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GB11332 Anti -SHIP-1 Rabbit pAb Antibody

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse SHIP1
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11332
  • Servicebio

Description

Product Information


Description

SHIP1 rabbit polyclonal

Protein full name

Phosphatidylinositol3,4,5-trisphosphate 5-phosphatase 1

Synonyms

SIP-145, hp51CN, p150Ship, inositol, SHIP1

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse SHIP1

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cell membrane, Cytoplasm

Uniprot ID

Q9ES52, P97573




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Mouse, Rat

1: 200-1: 1000

thymus, spleen

IF

Mouse, Rat

1: 200-1: 1000

thymus, spleen




Background


Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance.




Images



image.png

Immunohistochemistry analysis of paraffin-embedded rat thymus tissue using SHIP-1 (GB11332) at dilution of 1: 500

image.png

Immunohistochemistry analysis of paraffin-embedded mouse inflammation spleen using SHIP-1 (GB11332) at dilution of 1:500




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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