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GB11343 Anti -Nephrin Rabbit pAb Antibody

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse Nephrin
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11343
  • Servicebio

Description

Product Information


Description

Nephein rabbit polyclonal

Protein full name

Nephrin

Synonyms

NPHS1, CNF, NPHN, nephrin, NPHS1 nephrin, nephrin

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse Nephrin

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cell membrane

Uniprot ID

Q9QZS7




Applications


applications

species

dilution

Positive tissue

IHC

Mouse

1: 1500-1: 3000

kidney

IF

Mouse

1: 1500-1: 3000

kidney




Background


Nephrin is a protein necessary for the proper functioning of the renal filtration barrier. The renal filtration barrier consists of fenestrated endothelial cells, the glomerular basement membrane, and thepodocytes of epithelial cells. Nephrin is a transmembrane protein that is a structural component of the slit diaphragm. They are present on the tips of the podocytes and maintain the normal relationship between the basement membrane and the podocytes of the epithelial cells.

A defect in the gene for nephrin, NPHS1, is associated with congenital nephrotic syndrome of the Finnish typeand causes massive amounts of protein to be leaked into the urine, or proteinuria. Nephrin is also required for cardiovascular development.




Images



image.png

Immunohistochemistry analysis of paraffin-embedded mouse kidney using Nephrin (GB11343) at dilution of 1:3000.




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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