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GB11347 Anti -NADPH oxidase 4 Rabbit pAb Antibody

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse NOX4
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11347
  • Servicebio

Description

Product Information


Description

NADPH oxidase 4 rabbit polyclonal

Protein full name

NADPH oxidase 4

Synonyms

NOX4, KOX, KOX-1, RENOX, NADPH oxidase 4

Immunogen

KLH conjugated Synthetic peptide

corresponding to Mouse NOX4

Isotype

IgG

Predicted MW.

70 kDa

Observed MW.

70 kDa

Purity

Affinity purification

Subcellular location

Endoplasmic reticulum membrane,

Cell membrane, Cell junction

Uniprot ID

Q9JHI8, Q9NPH5, Q924V1




Applications


Applications

Species

Dilution

Positive Tissue

WB

Rat

1: 1000-1: 2000

skeletal muscle,

lung, kidney

IHC

Human, Mouse, Rat

1: 1000-1: 2000

kidney

IF

Human, Mouse, Rat

1: 1000-1: 2000

kidney




Background


Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. Nox4 protects the vasculature against inflammatory stress.Nox-dependent reactive oxygen species modulation by amino endoperoxides can induce apoptosis in high Nox4-expressing cancer cells.




Images



图片 4.png

Western blot analysis of NOX4 (GB11347)at dilution of 1: 1000.

Lane 1: Rat skeletal muscle tissue lysate

Lane 2: Rat lung tissue lysate

Lane 3:Rat kidney tissue lysate

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Immunohistochemistry analysis of parafffin-embedded human kidney using NOX4 (GB11347) at dilution of 1: 1000

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Immunohistochemistry analysis of parafffin-embedded mouse kidney using NOX4 (GB11347) at dilution of 1: 1000




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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