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GB11355 Anti -SIRT7 Sirtuin 7 Protein 7 Rabbit PAb Antibody

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse SIRT7
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11355
  • Servicebio

Description

Product Information


Description

SIRT7 rabbit polyclonal

Protein full name

NAD-dependent protein deacetylase sirtuin-7

Synonyms

SIRT7, SIR2L7, sirtuin 7, SIR2 like protein 7, Regulatory protein SIR2 homolog 7, Sir2 related protein type 7

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse SIRT7

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm, Nucleus

Uniprot ID

Q8BKJ9, Q9NRC8




Applications


applications

species

dilution

Positive tissue

IHC

Human

1: 200-1: 400

tonsil, lung cancer, stomach cancer

IF

Human

1: 200-1: 400

tonsil, lung cancer, stomach cancer




Background


NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions.




Images



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Immunohistochemistry analysis of paraffin-embedded human tonsil using SIRT7 (GB11355) at dilution of 1:200.

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Immunohistochemistry analysis of paraffin-embedded human lung cancer using SIRT7 (GB11355) at dilution of 1:200.

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Immunohistochemistry analysis of paraffin-embedded human stomach cancer using SIRT7 (GB11355) at dilution of 1:200.




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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