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GB11380 Anti -MGMT Rabbit pAb Antibody

Immunogen: Recombinant protein corresponding to Mouse MGMT
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11380
  • Servicebio

Description

Product Information


Description

MGMT rabbit polyclonal

Protein full name

Methylated-DNA--protein-cysteine methyltransferase

Synonyms

MGMT, Mgmt, AGT, AI267024, Agat, O-6-methylguanine-DNA methyltransferase

Immunogen

Recombinant protein corresponding to Mouse MGMT

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus

Uniprot ID

P26187, P24528




Applications


applications

species

dilution

Positive tissue

IHC

Mouse, Rat

1: 100-1: 500

skin, uters, spleen, heart, lymph node

IF

Mouse, Rat

1: 100-1: 500

skin, uters, spleen, heart, lymph node




Background


O6-alkylguanine DNA alkyltransferase (also known as AGT, MGMT or AGAT) is a protein that in humans is encoded by the O6-methylguanine DNA methyltransferase (MGMT) gene. O6-methylguanine DNA methyltransferase is crucial for genome stability. It repairs the naturally occurring mutagenic DNA lesion O6-methylguanine back to guanine and prevents mismatch and errors during DNA replication and transcription. Accordingly, loss of MGMT increases the carcinogenic risk in mice after exposure to alkylating agents.



Images



image.png

Immunohistochemistry analysis of paraffin-embedded mouse skin using MGMT (GB11380) at dilution of 1:300

image.png

Immunohistochemistry analysis of paraffin-embedded mouse uters using MGMT (GB11380) at dilution of 1:300

image.png

Immunohistochemistry analysis of paraffin-embedded rat lymph node using MGMT (GB11380) at dilution of 1:300




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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