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GB11399-1 Anti -ATG7 Rabbit pAb Antibody

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse ATG7
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11399-1
  • Servicebio

Description

Product Information


Description

ATG7 rabbit polyclonal

Protein full name

Ubiquitin-like modifier-activating enzyme ATG7

Synonyms

ATG7, APG7-LIKE, APG7L, GSA7, autophagy related 7, hAGP7

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse ATG7

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm

Uniprot ID

Q9D906, O95352




Applications


applications

species

dilution

Positive tissue

IHC

Human

1: 500-1: 1000

liver cancer, colon,

breast cancer

IF

Human

1: 500-1: 1000

liver cancer, colon,

breast cancer




Background


E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.




Images



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Immunohistochemistry analysis of paraffin-embedded human liver cancer using ATG7 (GB11399-1) at dilution of 1:1000.

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Immunohistochemistry analysis of paraffin-embedded human colon using ATG7(GB11399-1) at dilution of 1:1000.

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Immunohistochemistry analysis of paraffin-embedded human breast cancer using ATG7 (GB11399-1) at dilution of 1:1000.




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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