Ras homolog gene family, member A (RhoA) is a small GTPase protein in the Rho family. RhoA is primarily involved in these activities: actin organization, myosin contractility, cell cycle maintenance, cellular morphological polarization, cellular development and transcriptional control. There are many molecules can stimulate RhoA, such as NgR1, LINGO1, p75, TROY and other unknown receptors (e.g. by CSPGs). The
activated RhoA stimulates ROCK (RhoA kinase), which stimulates LIM kinase, which then stimulates cofilin, which effectively reorganizes the actin cytoskeleton of the cell.