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GB11517 Anti -p27 KIP 1 Rabbit pAb Antibody

Immunogen: KLH conjugated Synthetic peptide corresponding to Human p27 KIP 1.
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11517
  • Servicebio

Description

Product Information



Description

p27 KIP 1 rabbit polyclonal

Protein full name

Cyclin-dependent kinase inhibitor 1B

Synonyms

CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1, cyclin-dependent kinase inhibitor 1B, cyclin dependent kinase inhibitor 1B

Immunogen KLH conjugated Synthetic peptide corresponding to Human p27 KIP 1.
Isotype IgG
Purity Affinity purification
Subcellular location

Nucleus, Cytoplasm, Endosome

Uniprot ID P46527, P46414, O08769




Applications


Applications Species Dilution Positive Tissue
IHC Human 1: 500-1: 1500 colon, breast, esophagi, lung
IF Human, Rat 1: 500-1: 1500 lung, sepsis brain, kidney




Background



The p27Kip1 gene has a DNA sequence similar to other members of the "Cip/Kip" family which include the p21Cip1/Waf1 and p57Kip2 genes.  p27Kip1 can bind to cyclin D either alone, or when complexed to its catalytic subunit CDK4, which inhibits the catalytic activity of Cdk4, preventing Cdk4 from adding phosphate residues to the retinoblastoma (pRb) protein. Increased levels of the p27Kip1 protein typically cause cells to arrest in the G1 phase of the cell cycle. Likewise, p27Kip1 is able to bind other Cdk proteins when complexed to cyclin subunits such as Cyclin E/Cdk2 and Cyclin A/Cdk2.




Images



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Immunohistochemistry analysis of paraffin-embedded human lung cancer using p27 KIP 1 (GB11517) at dilution of 1:1500


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Immunohistochemistry analysis of paraffin-embedded human colon using p27 KIP 1 (GB11517) at dilution of 1:1500

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Immunohistochemistry analysis of paraffin-embedded human colon cancer using p27 KIP 1 (GB11517) at dilution of 1:1500

image.png

Immunohistochemistry analysis of paraffin-embedded human breast  using p27 KIP 1 (GB11517) at dilution of 1:1500

image.png

Immunohistochemistry analysis of paraffin-embedded human breast cancer using p27 KIP 1 (GB11517) at dilution of 1:1500

image.png

Immunohistochemistry analysis of paraffin-embedded human esophagi cancer using p27 KIP 1 (GB11517) at dilution of 1:1500


Immunofluorescent analysis of paraformaldehyde-fixed human lung using p27 KIP 1 (GB11517) at dilution of 1:500



Immunofluorescent analysis of paraformaldehyde-fixed rat lung using p27 KIP 1 (GB11517) at dilution of 1:500



Immunofluorescent analysis of paraformaldehyde-fixed rat sepsis brain using p27 KIP 1 (GB11517) at dilution of 1:500



Immunofluorescent analysis of paraformaldehyde-fixed human kidney using p27 KIP 1 (GB11517) at dilution of 1:500






Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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