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GB11522 Anti -CD45 PTPRC T200 LY5 LCA Rabbit Polyclonal Antibody for WB

Immunogen: Recombinant protein corresponding to human CD45
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11522
  • Servicebio

Description

Product Information


Description CD45 rabbit polyclonal
Protein full name Receptor-type tyrosine-protein phosphatase C
Synonyms PTPRC, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, protein tyrosine phosphatase, receptor type C
Immunogen Recombinant protein corresponding to human CD45.
Isotype IgG
Purity Affinity purification
Predicted MW. 147 KDa
Observed MW. 180 KDa
Uniprot ID P08575, P06800




Applications


applications species dilution Positive tissue
WB Human, Mouse 1:500-1:1000 THP-1, thymus, lymph gland




Background



PTPRC is also known as CD45 antigen, which was originally called leukocyte common antigen (LCA). The encoded protein is a member of the protein tyrosine phosphatase (PTP) family. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP, specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling. It also suppresses JAK kinases and functions as a negative regulator of cytokine receptor signaling.




Images



image.png

Western blot analysis of CD45 (GB11522) at dilution of 1:1000.

Lane 1: Jurkat cell lysate

Lane 2: Raw264.7 cell lysate

Lane 3: THP-1 cell lysate

Lane 4: Mouse thymus tissue lysate

Lane 5: Mouse lymph gland tissue lysate




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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