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GB11534 Anti -IL-10 CSIF GVHDS IL10A Rabbit Polyclonal Antibody for IHC IF

Immunogen: Recombinant protein corresponding to Mouse IL-10
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11534
  • Servicebio

Description

Product Information


Description

IL-10 rabbit polyclonal

Protein full name

Interleukin-10

Synonyms

IL10, CSIF, GVHDS, IL-10, IL10A, TGIF,

interleukin 10, Cytokine Synthesis Inhibitory Factor, Interleukin-10 precursor

Immunogen

Recombinant protein corresponding to

Mouse IL-10

Isotype

IgG

Purity

Affinity purification

Subcellular location

Secreted

Uniprot ID

P18893, P29456




Applications


applications

species

dilution

Positive tissue

IHC

Mouse, Rat

1: 200-1: 1000

inflammatory lung, inflammatory liver, inflammatory spleen

IF

Mouse, Rat

1: 200-1: 1000

inflammatory lung, inflammatory liver, inflammatory spleen




Background


IL-10 is a cytokine with multiple, pleiotropic, effects in immunoregulation and inflammation. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as IFN-γ, IL-2, IL-3, TNFα and GM-CSF made by cells such as macrophages and Th1 T cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells. IL-10 is linked to the myokines, as exercise provokes an increase in circulating levels of IL-1ra, IL-10, and sTNF-R, suggesting that physical exercise fosters an environment of anti-inflammatory cytokines.




Images



image.png

Immunohistochemistry analysis of paraffin-embedded mouse inflammatory lung using IL-10 (GB11534) at dilution of 1: 500

image.png

Immunohistochemistry analysis of paraffin-embedded rat inflammatory lung using IL-10 (GB11534) at dilution of 1: 500

image.png

Immunohistochemistry analysis of paraffin-embedded rat inflammatory spleen using IL-10 (GB11534) at dilution of 1: 1000




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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