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GB11542 Anti -YAP1 COB1 YAP YAP65 Rabbit Polyclonal Antibody for WB

Immunogen: Recombinant protein corresponding to Mouse YAP1
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11542
  • Servicebio

Description

Product Information


Description YAP1 rabbit polyclonal
Protein full name Transcriptional coactivator YAP1
Synonyms YAP1, COB1, YAP, YAP2, YAP65, YKI, Yes associated protein 1, Yap
Immunogen Recombinant protein corresponding to
Mouse YAP1
Isotype IgG
Purity Affinity purification
Predicted MW. 52 KDa
Observed MW. 65 KDa
Uniprot ID P46937, P46938, Q2EJA0




Applications


applications species dilution Positive tissue
WB Human,Mouse,Rat 1:500-1:1000 heart, kidney




Background



YAP1 is a transcriptional co-activator and its proliferative and oncogenic activity is driven by its association with the TEAD family of transcription factors, which up-regulate genes that promote cell growth and inhibit apoptosis. Several other functional partners of YAP1 were identified, including RUNX, SMADs, p73, ErbB4,TP53BP, LATS1/2, PTPN14, AMOTs, and ZO1/2. YAP1 and its close paralog, TAZ (WWTR1), are the main effectors of the Hippo tumor suppressor pathway.When the pathway is activated, YAP1 and TAZ are phosphorylated on a serine residue and sequestered in the cytoplasm by 14-3-3 proteins. When the Hippo pathway is not activated, YAP1/TAZ enter the nucleus and regulate gene expression.




Images



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Western blot analysis of YAP1 (GB11542) at dilution of 1:800.

Lane 1:HepG2 cell lysate

Lane 2:A549 cell lysate

Lane 3:HUVEC cell lysate

Lane 4:Mouse heart tissue lysate

Lane 5:Mouse kidney tissue lysate

Lane 6:Rat heart tissue lysate

Lane 7:Rat kidney tissue lysate




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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