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GB11543 Anti -Raf1 CMD1NN CRAF NS5 Rabbit Polyclonal Antibody for WB

Immunogen: Recombinant protein corresponding to Mouse c-Raf
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11543
  • Servicebio

Description

Product Information



Description

Raf1 rabbit polyclonal

Protein full name RAF proto-oncogene serine/threonine-protein kinase

Synonyms

RAF1, Raf-1 proto-oncogene,serine/threonine kinase, CMD1NN, CRAF,NS5,  Raf-1, c-Raf

Immunogen Recombinant protein corresponding to Mouse c-Raf
Isotype IgG
Purity Affinity purification

Predicted MW.

73 kDa

Observed MW.

73 kDa

Uniprot ID

P04049, Q99N57, P11345




Applications



Applications

WB

Species

Human,Mouse,Rat

Dilution

1:500-1:1000

Positive tissue

lung, kidney, testis




Background



RAF proto-oncogene serine/threonine-protein kinase, also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1, is an enzyme that in humans is encoded by the RAF1 gene. The c-Raf protein is part of the ERK1/2 pathway as a MAP kinase kinase kinase (MAP3K) that functions downstream of the Ras subfamily of membrane associated GTPases. C-Raf is a member of the Raf kinase family of serine/threonine-specific protein kinases, from the TKL (Tyrosine-kinase-like) group of kinases. Although c-Raf is very clearly capable of mutating into an oncogene in experimental settings, and even in a few human tumors, its sister kinase B-Raf is the true major player in carcinogenesis in humans.




Images



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Western blot analysis of c-Raf (GB11543) at dilution of 1:800.

Lane 1:MCF cell lysate

Lane 2:A431 cell lysate

Lane 3:A549 cell lysate

Lane 4:Mouse lung tissue lysate

Lane 5:Mouse kidney tissue lysate

Lane 6:Mouse testis tissue lysate

Lane 7:Rat lung tissue lysate

Lane 8:Rat kidney tissue lysate

Lane 9:Rat testis tissue lysate




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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