Mitogen-activated protein kinase 3 is an enzyme that in humans is encoded by the MAPK3 gene. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Pharmacological inhibition of ERK1/2 restores GSK3β activity and protein synthesis levels in a model of tuberous sclerosis.
Western blot analysis of ERK1 + ERK2
(GB11560) at dilution of 1: 1000.
Lane 1: HepG2 cell lysate
Lane 2: MCF7 cell lysate
Lane 3: A549 cell lysate
Lane 4: Mouse liver tissue lysate
Lane 5: Mouse lung tissue lysate
Lane 6: Mouse brain tissue lysate
Lane 7: Rat liver tissue lysate
Lane 8: Rat lung tissue lysate
Lane 9: Rat brain tissue lysate
Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.