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GB11569 Anti - PLCγ1 PLC1 PLC148 Rabbit Polyclonal Antibody

Immunogen: Recombinant protein corresponding to Mouse PLCγ1
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11569
  • Servicebio

Description

Product Information


Description

PLCγ1 rabbit polyclonal

Protein full name

1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase gamma-1

Synonyms

PLCG1, NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1, Phospholipase C gamma 1, PLCγ1

Immunogen

Recombinant protein corresponding to Mouse PLCγ1

Isotype

IgG

Purity

Affinity purification

Predicted MW.

149 kDa

Observed MW.

160 kDa

Uniprot ID

P19174




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human

1: 500-1: 1000

Jurkat, MCF7, HeLa




Background


Phospholipase C, gamma 1, also known as PLCG1, is a protein that in humans is encoded by the PLCG1 gene. This protein catalyzes the formation of inositol 1, 4, 5-trisphosphate and diacylglycerol from phosphatidylinositol 4, 5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1(acidic fibroblast growth factor) -activated tyrosine kinase.




Images



wb-10.jpg

Western blot analysis of PLCγ1

(GB11569) at dilution of 1: 800

Lane 1: Jurkat cell lysate

Lane 2: MCF7 cell lysate

Lane 3: HeLa cell lysate




Storage



Storage

Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.

Storage Buffer

PBS with 0.02%sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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