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GB11580 Anti -ULK1 Rabbit pAb Antibody

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse ULK1
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11580
  • Servicebio

Description

Product Information


Description

ULK1 rabbit polyclonal

Protein full name

Serine/threonine-protein kinase ULK1

Synonyms

ULK1, ATG1, ATG1A, UNC51, Unc51.1, hATG1, unc-51 like autophagy activating kinase 1

Immunogen

KLH conjugated Synthetic peptide

corresponding to Mouse ULK1

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm

Uniprot ID

O70405




Applications


applications

species

dilution

positive tissue

IHC

Mouse, Rat

1: 500-1: 1000

lung, liver

IF

Mouse, Rat

1: 500-1: 1000

lung, liver




Background


ULK1 belongs to the serine/threonine protein kinase family. It is involved in axon growth and plays an essential role in neurite branching during sensory axon outgrowth. Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity.




Images



image.png

Immunohistochemistry analysis of paraffin-embedded mouse lung using

ULK1 (GB11580) at dilution of 1: 1000


image.png

Immunohistochemistry analysis of paraffin-embedded rat lung using

ULK1 (GB11580) at dilution of 1: 500


image.png

Immunohistochemistry analysis of paraffin-embedded rat liver using

ULK1 (GB11580) at dilution of 1: 500





Storage



Storage

Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles

Storage Buffer

PBS with 0.02%sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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