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GB11599 Anti -ErbB2 Rabbit pAb Antibody

Immunogen: Recombinant protein corresponding to Mouse ErbB2
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11599
  • Servicebio

Description

Product Information


Description

ErbB2 rabbit polyclonal

Protein full name

Receptor tyrosine-protein kinase erbB-2

Synonyms

ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, erb-b2 receptor tyrosine kinase 2, ErbB2

Immunogen

Recombinant protein corresponding to Mouse ErbB2

Isotype

IgG

Purity

Affinity purification

Predicted MW.

139 kDa

Observed MW.

185 kDa

Uniprot ID

P04626, P70424, P06494




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

uterus, ovary




Background


The ErbB family consists of four plasma membrane-bound receptor tyrosine kinases. One of which is erbB-2, and the other members being epidermal growth factor receptor, erbB-3 (neuregulin-binding; lacks kinase domain), and erbB-4. All four contain an extracellular ligand binding domain, a transmembrane domain, and an intracellular domain that can interact with a multitude of signaling molecules and exhibit both ligand-dependent and ligand-independent activity. Notably, no ligands for HER2 have yet been identified. HER2 can heterodimerise with any of the other three receptors and is considered to be the preferred dimerisation partner of the other ErbB receptors. Dimerisation results in the autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptors and initiates a variety of signaling pathways.




Images



image.png

Western blot analysis of ErbB2

(GB11599) at dilution of 1: 1000

Lane 1: HeLa cell lysate

Lane 2: MCF7 cell lysate

Lane 3: SKBR3 cell lysate

Lane 4: SKOV3 cell lysate

Lane 5: AN3CA cell lysate

Lane 6: Mouse uterus tissue lysate

Lane 7: Mouse ovary tissue lysate

Lane 8: Rat uterus tissue lysate





Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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