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GB11609 Anti -HP1 alpha Rabbit pAb Antibody

Immunogen: Recombinant protein corresponding to Mouse HP1 alpha
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11609
  • Servicebio

Description

Product Information


Description

HP1 alpha rabbit polyclonal

Protein full name

Chromobox protein homolog 5

Synonyms

CBX5, HEL25, HP1, HP1A, chromobox 5, HP1 alpha

Immunogen

Recombinant protein corresponding to Mouse HP1 alpha

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus

Predicted MW.

22 kDa

Observed MW.

22 kDa

Uniprot ID

P45973, Q61686




Applications


applications

species

dilution

positive tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

brain, kidney, testis

IHC

Human, Mouse, Rat

1: 500-1: 1000

mammary gland,

brain

IF

Mouse, Rat

1: 500-1: 1000

thyroid, sepsis brain, placenta




Background


Chromobox protein homolog 5 is a protein that in humans is encoded by the CBX5 gene. It is a highly conserved, non-histone protein part of the heterochromatin family. The protein itself is more commonly called (in humans) HP1α. Heterochromatin protein-1 (HP1) has an N-terminal domain that acts on methylated lysines residues leading to epigenetic repression. The C-terminal of this protein has a chromo shadow-domain (CSD) that is responsible for homodimerizing, as well as interacting with a variety of chromatin-associated, non-histone proteins.




Images



image.png

Western blot analysis of HP1 alpha (GB11609) at dilution of 1: 1000

Lane 1: HeLa cell lysate

Lane 2: MCF7 cell lysate

Lane 3: A431 cell lysate

Lane 4: Mouse brain tissue lysate

Lane 5: Mouse kidney tissue lysate

Lane 6: Mouse testis tissue lysate

Lane 7: Rat brain tissue lysate

Lane 8: Rat kidney tissue lysate

Lane 9: Rat testis tissue lysate


image.png

Immunohistochemistry analysis of paraffin-embedded human mammary gland using HP1 alpha (GB11609) at dilution of 1: 1000

Immunohistochemistry analysis of paraffin-embedded mouse brain using

HP1 alpha (GB11609) at dilution of 1: 1000


Immunohistochemistry analysis of paraffin-embedded rat brain using

HP1 alpha (GB11609) at dilution of 1: 1000


Immunofluorescent analysis of paraformaldehyde-fixed mouse placenta using HP1 alpha (GB11609) at dilution of 1: 1000

Immunofluorescent analysis of paraformaldehyde-fixed mouse thyroid using HP1 alpha (GB11609) at dilution of 1: 1000


Immunofluorescent analysis of paraformaldehyde-fixed rat sepsis brain using

HP1 alpha (GB11609) at dilution of 1: 1000




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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