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GB11617 Anti -C2 Rabbit pAb Antibody

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse Complement C2
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11617
  • Servicebio

Description

Product Information


Description

C2 rabbit polyclonal

Protein full name

Complement C2

Synonyms

C2, ARMD14, CO2, Complement component 2, Complement C2

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse Complement C2

Isotype

IgG

Purity

Affinity purification

Predicted MW.

85 kDa

Observed MW.

102 kDa

Uniprot ID

P21180, P06681, Q6MG73




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

liver, lung, stomach




Background


Complement C2 is a protein that in humans is encoded by the C2 gene. The protein encoded by this gene is part of the classical pathway of the complement system, acting as a multi-domain serine protease. Deficiency of C2 has been associated with certain autoimmune diseases. In the classical and lectin pathways of complement activation, formation of the C3-convertase and C5-convertases requires binding of C2 to an activated surface-bound C4b in the presence of Mg2+; the resultant C4bC2 complex is then cleaved by C1s or MASP2 into C2a and C2b. It is thought that cleavage of C2 by C1s, while bound to C4b, results in a conformational rotation of C2b whereas the released C2a fragment may retain most of its original structure.




Images



上传.jpg

Western blot analysis of Complement C2 (GB11617) at dilution of 1: 1000

Lane 1: HeLa cell lysate

Lane 2: HepG2 cell lysate

Lane 3: A431 cell lysate

Lane 4: Mouse liver tissue lysate

Lane 5: Mouse lung tissue lysate

Lane 6: Rat liver tissue lysate

Lane 7: Rat stomach tissue lysate





Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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