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GB11622 Anti -Frizzled 5 Rabbit pAb Antibody

Immunogen: Recombinant protein corresponding to Mouse Frizzled 5
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11622
  • Servicebio

Description

Product Information


Description

Frizzled 5 rabbit polyclonal

Protein full name

Frizzled-5

Synonyms

FZD5, C2orf31, HFZ5, frizzled class receptor 5, Frizzled 5

Immunogen

Recombinant protein corresponding to Mouse Frizzled 5

Isotype

IgG

Purity

Affinity purification

Predicted MW.

64 kDa

Observed MW.

50 kDa

Uniprot ID

Q9EQD0, Q13467, Q8CHL0




Applications


Applications

Species

Dilution

Positive Tissue

WB

Mouse, Rat

1: 500-1: 1000

epencephalon, brain,

cortex, small intestine




Background


Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta-catenin pathway.



Images



image.png

Western blot analysis of Frizzled 5 (GB11622) at dilution of 1: 1000

Lane 1: Mouse epencephalon tissue lysate

Lane 2: Mouse brain tissue lysate

Lane 3: Mouse cortex tissue lysate

Lane 4: Mouse small intestine tissue lysate

Lane 5: Rat epencephalon tissue lysate

Lane 6: Rat brain tissue lysate

Lane 7: Rat cortex tissue lysate

Lane 8: Rat small intestine tissue lysate





Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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