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Anti -p53 Rabbit PAb for Western Blot IHC IF Primary Antibody

Specification: 100uL
  • GB11626
  • Servicebio
  • Servicebio

Description

Product Information


Description

p53 rabbit polyclonal

Protein full name

Cellular tumor antigen p53

Synonyms

TP53, BCC7, LFS1, P53, TRP53, tumor protein p53

Immunogen

Recombinant protein corresponding to Human p53

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus, Endoplasmic reticulum, Mitochondrion

Predicted MW.

43 kDa

Observed MW.

53 kDa

Uniprot ID

P04637




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human

1: 1000-1:2000

liver cancer,

stomach cancer

IHC

Human

1: 1000-1: 2000

lung adenocarcinoma, ovary

IF

Human

1: 500-1: 1000

lung adenocarcinoma, ovary




Background


Tumor protein p53, also known as p53, cellular tumor antigen p53 , phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), which encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, sense cence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome.




Images



image.png

Western blot analysis of p53 (GB11626)

at dilution of 1: 1000

Lane 1: HT29 cell lysate

Lane 2: H1299 cell lysate

Lane 3: 293 cell lysate

Lane 4: A549 cell lysate

Lane 5: Human liver cancer tissue lysate

Lane 6: Human stomach cancer tissue lysate


image.png

Immunohistochemistry analysis of paraffin-embedded human lung adenocarcinoma using p53 (GB11626)

at dilution of 1: 1600


image.png

Immunohistochemistry analysis of paraffin-embedded human ovary

using p53 (GB11626) at dilution of 1: 1600





Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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