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Anti -PARK7/DJ1 Rabbit PAb for WB Experiment Protein Detection Antibody

Specification: 100uL
  • GB11640
  • Servicebio
  • Servicebio

Description

Product Information


Description

PARK7/DJ1 rabbit polyclonal

Protein full name

Protein/nucleic acid deglycase DJ-1

Synonyms

PARK7, DJ-1, DJ1, HEL-S-67p, Parkinsonism associated deglycase, GATD2

Immunogen

Recombinant protein corresponding to Mouse PARK7

Isotype

IgG

Purity

Affinity purification

Predicted MW.

20 kDa

Observed MW.

24 kDa

Uniprot ID

Q99497, Q99LX0, O88767




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

heart, liver,

kidney, brain




Background


Protein deglycase DJ-1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene. Under an oxidative condition, protein deglycase DJ-1 inhibits the aggregation of α-synuclein via its chaperone activity, thus functions as a redox-sensitive chaperone and as a sensor for oxidative stress. Accordingly, DJ-1 apparently protects neurons against oxidative stress and cell death. In parallel, Protein DJ-1 acts as a positive regulator of androgen receptor-dependent transcription. Pyrroloquinoline quinone (PQQ) has been shown to reduce the self-oxidation of the DJ-1 protein, an early step in the onset of some forms of Parkinson's disease. Functional DJ-1 protein has been shown to bind metals and protect against metal-induced cytotoxicity from copper and mercury.




Images



2.jpg

Western blot analysis of PARK7

(GB11640) at dilution of 1: 500

Lane 1: Human brain tissue lysate

Lane 2: Mouse heart tissue lysate

Lane 3: Mouse liver tissue lysate

Lane 4: Mouse kidney tissue lysate

Lane 5: Mouse brain tissue lysate

Lane 6: Rat heart tissue lysate

Lane 7: Rat liver tissue lysate

Lane 8: Rat kidney tissue lysate

Lane 9: Rat brain tissue lysate





Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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