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Anti -Bora Rabbit PAb for IHC IF Cell Cycle Research Antibody

Specification: 100uL
  • GB11647
  • Servicebio
  • Servicebio

Description

Product Information


Description

Bora rabbit polyclonal

Protein full name

Protein aurora borealis

Synonyms

Aurora borealis, Bora, BORA, C13orf34, Chromosome 13 open reading frame 34, FLJ22624, HsBora, Protein aurora borealis, RP11-342J4.2

Immunogen

Recombinant protein corresponding to Mouse Bora

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm

Uniprot ID

Q8BS90




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Mouse, Rat

1: 200-1: 400

heart, lung

IF

Mouse, Rat

1: 100-1: 200

cerebellum, liver, lung, testis




Background


Aurora related kinase-1 (ARK-1) is a centrosome-associated serine/threonine kinase that regulates centrosome separation, bipolar spindle assembly and chromosome segregation during mitosis. Bora (protein aurora borealis) is a 559 amino acid protein that activates ARK-1. Bora is localized to the nucleus until mitosis is initiated, when it then translocates to the cytoplasm. This translocation is dependent on activated Cdc2, which releases Bora to bind and activate ARK-1 in the cytoplasm. Plk (polo-like kinase) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation on its N-terminus by ARK-1. It is through this mechanism that Bora and ARK-1 control cellular mitotic entry. Downregulation of the gene encoding Bora results in multipolar spindles in mitosis, a phenomenon that is also observed when ARK-1 function is blocked.




Images



image.png

Immunohistochemistry analysis of paraffin-embedded rat heart using

Bora (GB11647) at dilution of 1: 200


image.png

Immunohistochemistry analysis of paraffin-embedded mouse lung using

Bora (GB11647) at dilution of 1: 200


Immunofluorescent analysis of paraformaldehyde-fixed mouse cerebellum using Bora (GB11647) at dilution of 1: 200


Immunofluorescent analysis of paraformaldehyde-fixed rat liver using

Bora (GB11647) at dilution of 1: 200

Immunofluorescent analysis of paraformaldehyde-fixed rat lung using

Bora (GB11647) at dilution of 1: 200


Immunofluorescent analysis of paraformaldehyde-fixed rat testis using

Bora (GB11647) at dilution of 1: 200




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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