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Anti -BNP Rabbit PAb Western Blot Antibody

Specification:100uL
  • GB11667
  • Servicebio
  • Servicebio

Description

Product Information


Description

BNP rabbit polyclonal

Protein full name

Natriuretic peptides B

Synonyms

NPPB, BNP, natriuretic peptide B, brain natriuretic peptide, B-type natriuretic peptide

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse BNP

Isotype

IgG

Purity

Affinity purification

Predicted MW.

15 kDa

Observed MW.

30 kDa

Uniprot ID

P40753, P13205




Applications


Applications

Species

Dilution

Positive Tissue

WB

Mouse, Rat

1: 500-1: 1500

brain, hippocampus,

cerebral cortex




Background


Brain natriuretic peptide (BNP), also known as B-type natriuretic peptide, is a hormone secreted by cardiomyocytes in the heart ventricles in response to stretching caused by increased ventricular blood volume. BNP is synthesized as a 134-amino acid preprohormone (preproBNP), encoded by the human gene NPPB. Removal of the 25-residue N-terminal signal peptide generates the prohormone, proBNP, which is stored intracellularly as an O-linked glycoprotein; proBNP is subsequently cleaved between arginine-102 and serine-103 by a specific convertase (probably furin or corin) into NT-proBNP and the biologically active 32-amino acid polypeptide BNP-32, which are secreted into the blood in equimolar amounts. Cleavage at other sites produces shorter BNP peptides with unknown biological activity. Processing of proBNP may be regulated by O-glycosylation of residues near the cleavage sites.



Images



内页.jpg

Western blot analysis of BNP (GB11667)

at dilution of 1: 1000

Lane 1: Mouse brain tissue lysate

Lane 2: Mouse cerebral cortex tissue lysate

Lane 3: Mouse hippocampus tissue lysate

Lane 4: Rat brain tissue lysate

Lane 5: Rat cerebral cortex tissue lysate

Lane 6: Rat hippocampus tissue lysate





Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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