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Anti -MEK4 Rabbit pAb primary antibody for western blot

Specification:100uL
  • GB11691
  • Servicebio
  • Servicebio

Description

Product Information


Description

MEK4 rabbit polyclonal

Protein full name

Dual specificity mitogen-activated protein kinase kinase 4

Synonyms

MAP2K4, JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1, mitogen-activated protein kinase kinase 4, JNK activating kinase 1, c-Jun N-terminal kinase kinase 1

Immunogen

Recombinant protein corresponding to Mouse MEK4

Isotype

IgG

Purity

Affinity purification

Predicted MW.

44 kDa

Observed MW.

44 kDa

Uniprot ID

P45985, P47809




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

liver, brain, spinal cord




Background


Dual specificity mitogen-activated protein kinase kinase 4 is an enzyme that in humans is encoded by the MAP2K4 gene. This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK1. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.




Images



上传-2.jpg

Western blot analysis of MEK4 (GB11691)

at dilution of 1: 1000

Lane 1: 293T cell lysate

Lane 2: NIH/3T3 cell lysate

Lane 3: Raw264.7 cell lysate

Lane 4: Mouse liver tissue lysate

Lane 5: Mouse brain tissue lysate

Lane 6: Mouse spinal cord tissue lysate

Lane 7: Rat liver tissue lysate

Lane 8: Rat brain tissue lysate

Lane 9: Rat spinal cord tissue lysate





Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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