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Anti -CD40 Rabbit PAb for Western Blot

Specification: 100uL
  • GB11702
  • Servicebio
  • Servicebio

Description

Product Information


Description

CD40 rabbit polyclonal

Protein full name

Tumor necrosis factor receptor superfamily member 5

Synonyms

B-cell surface antigen CD40, Bp50, CD40L receptor, CD40, Tnfrsf5, CDw40, GP39, HIGM1, IGM, IMD3, TBAM

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse CD40

Isotype

IgG

Purity

Affinity purification

Predicted MW.

32 kDa

Observed MW.

45 kDa

Uniprot ID

P27512, Q4QQW2




Applications


Applications

Species

Dilution

Positive Tissue

WB

Mouse, Rat

1: 500-1: 1000

splenitis, thymitis, pneumonia




Background


Cluster of differentiation 40, CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 is  is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The TNFR-receptor associated factor adaptor proteins TRAF1, TRAF2, TRAF6 and possibly TRAF5 interact with this receptor serve as mediators of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.




Images



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Western blot analysis of CD40 (GB11702)

at dilution of 1: 1000

Lane 1: A20 cell lysate

Lane 2: Mouse splenitis tissue lysate

Lane 3: Mouse thymitis tissue lysate

Lane 4: Rat splenitis tissue lysate

Lane 5: Rat pneumonia tissue lysate

Lane 6: Rat thymitis tissue lysate




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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