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Anti -PRAK Rabbit pAb For IHC IF

Specification: 100uL
  • GB11721
  • Servicebio
  • Servicebio

Description

Product Information


Description

PRAK rabbit polyclonal

Protein full name

MAP kinase-activated protein kinase 5

Synonyms

Mapkapk5, PRAK, MAPKAPK5, MAPKAP-K5, MK-5, MK5, PRAK, mitogen-activated protein kinase-activated protein kinase 5

Immunogen

Recombinant protein corresponding to Mouse PRAK

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus

Uniprot ID

Q8IW41, O54992




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Human, Mouse, Rat

1: 1000-1: 2000

liver, lung

IF

Human, Mouse, Rat

1: 500-1: 1000

liver, lung




Background


MAP kinase-activated protein kinase 5 is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases, including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately-spliced transcript variants of this gene encoding distinct isoforms have been reported. A link between Alzheimer's disease and reduced levels of MAPKAPK5 has been proposed. Clinical trials may confirm if this is the case.




Images



image.png


Immunohistochemistry analysis of paraffin-embedded human liver using

PRAK (GB11721) at dilution of 1: 1000



image.png

Immunohistochemistry analysis of paraffin-embedded mouse lung using

PRAK (GB11721) at dilution of 1: 1000


image.png

Immunohistochemistry analysis of paraffin-embedded rat lung using

PRAK (GB11721) at dilution of 1: 1000





Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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